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Evidence for multi-site ligand binding and stretching of filamin by integrin and migfilin
Filamin, a large cytoskeletal adaptor, connects plasma membrane to cytoskeleton by binding to transmembrane receptor integrin and actin. Seven of twenty-four filamin immunoglobulin repeats have conserved integrin binding sites, of which 19 and 21 were shown to be auto-inhibited by their adjacent rep...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097901/ https://ncbi.nlm.nih.gov/pubmed/21524097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2003229 |
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