Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

Noonan syndrome is a relatively common developmental disorder that is characterized by reduced growth, wide-set eyes and congenital heart defects. Noonan syndrome is associated with dysregulation of the Ras–mitogen-activated-protein-kinase (MAPK) signaling pathway. Recently, two mutations in NRAS we...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Runtuwene, Vincent, van Eekelen, Mark, Overvoorde, John, Rehmann, Holger, Yntema, Helger G., Nillesen, Willy M., van Haeringen, Arie, van der Burgt, Ineke, Burgering, Boudewijn, den Hertog, Jeroen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Limited 2011
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097460/
https://ncbi.nlm.nih.gov/pubmed/21263000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.007112
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak