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Genetic Enhancement of the Lis1+/− Phenotype by a Heterozygous Mutation in the Adenomatous Polyposis Coli Gene
Hemizygous Lis1 mutations cause type 1 lissencephaly, a neuronal migration disorder in humans. The Lis1+/− mouse is a model for lissencephaly; mice exhibit neuronal migration defects but are viable and fertile. On an inbred genetic background, 20% of Lis1+/− mice develop hydrocephalus and die premat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097246/ https://ncbi.nlm.nih.gov/pubmed/18075263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000109860 |
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