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EXTRA-HEPATIC CANCER SUPPRESSES NUCLEAR RECEPTOR REGULATED DRUG METABOLISM
PURPOSE: To determine the mechanisms by which tumors situated in extra-hepatic sites can cause profound changes in hepatic drug clearance, contributing to altered drug response and chemotherapy resistance. EXPERIMENTAL DESIGN: We studied in wild type or transgenic CYP3A4 reporter mice implanted with...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3096719/ https://ncbi.nlm.nih.gov/pubmed/21498392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3289 |
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