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Differential Roles for the Interferon-inducible IFI16 and AIM2 Innate Immune Sensors for Cytosolic DNA in Cellular Senescence of Human Fibroblasts

The interferon (IFN)-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic double-stranded DNA (dsDNA). Upon sensing dsDNA, the IFI16 protein induces the expression of IFN-β whereas the AIM2 protein forms an inflammasome, which promotes the secretion of IL-1β. Given that the k...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Duan, Xin, Ponomareva, Larissa, Veeranki, Sudhakar, Panchanathan, Ravichandran, Dickerson, Eric, Choubey, Divaker
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096691/
https://ncbi.nlm.nih.gov/pubmed/21471287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-10-0565
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