The P2 Receptor Antagonist PPADS Supports Recovery from Experimental Stroke In Vivo

BACKGROUND: After ischemia of the CNS, extracellular adenosine 5′-triphosphate (ATP) can reach high concentrations due to cell damage and subsequent increase of membrane permeability. ATP may cause cellular degeneration and death, mediated by P2X and P2Y receptors. METHODOLOGY/PRINCIPAL FINDINGS: Th...

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Main Authors: Lämmer, Alexandra B., Beck, Alexander, Grummich, Benjamin, Förschler, Annette, Krügel, Thomas, Kahn, Thomas, Schneider, Dietmar, Illes, Peter, Franke, Heike, Krügel, Ute
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096654/
https://ncbi.nlm.nih.gov/pubmed/21611146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019983
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