IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis

Receptor endocytosis is critical for cell signaling. IGF1R mediates an autocrine loop that is de-regulated in Ewing Sarcoma (ES) cells. Here we study the impact of IGF1R internalization, mediated by clathrin and caveolin-1 (CAV1), in ES signaling. We used clathrin and CAV1-siRNA to interfere in clat...

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Detalhes bibliográficos
Main Authors: Martins, Ana Sofia, Ordóñez, José Luis, Amaral, Ana Teresa, Prins, Frans, Floris, Giuseppe, Debiec-Rychter, Maria, Hogendoorn, Pancras C. W., de Alava, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096649/
https://ncbi.nlm.nih.gov/pubmed/21611203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019846
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