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Incorporation of the catalytic domain of a hammerhead ribozyme into antisense RNA enhances its inhibitory effect on the replication of human immunodeficiency virus type 1.

The catalytic domain of a hammerhead ribozyme was incorporated into a 413 nucleotides long antisense RNA directed against the 5'-leader/gag region of the human immunodeficiency virus type 1 (HIV-1) (pos. +222 to +634). The resulting catalytic antisense RNA was shown to cleave its target RNA in...

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Main Authors: Homann, M, Tzortzakaki, S, Rittner, K, Sczakiel, G, Tabler, M
格式: Artigo
語言:Inglês
出版: 1993
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC309658/
https://ncbi.nlm.nih.gov/pubmed/8332489
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