In vivo transcription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide.

Oligonucleotides provide novel reagents for inhibition of gene expression because of their high affinity binding to specific nucleotide sequences. We describe a 38 base, single-stranded DNA that forms a triple helix or 'triplex' on progesterone response elements of a target gene. This trip...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Ing, N H, Beekman, J M, Kessler, D J, Murphy, M, Jayaraman, K, Zendegui, J G, Hogan, M E, O'Malley, B W, Tsai, M J
Format: Artigo
Language:Inglês
Published: Oxford University Press 1993
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309654/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8332487/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.12.2789
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