Caveolin-1 Maintains Activated Akt in Prostate Cancer Cells through Scaffolding Domain Binding Site Interactions with and Inhibition of Serine/Threonine Protein Phosphatases PP1 and PP2A

Previously it has been reported that caveolin-1 (cav-1) has antiapoptotic activities in prostate cancer cells and functions downstream of androgenic stimulation. In this study, we demonstrate that cav-1 overexpression significantly reduced thapsigargin (Tg)-stimulated apoptosis. Examination of the p...

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Autores principales: Li, Likun, Ren, Cheng Hui, Tahir, Salahaldin A., Ren, Chengzhen, Thompson, Timothy C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC309640/
https://ncbi.nlm.nih.gov/pubmed/14645548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.9389-9404.2003
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