Multiple Genetic Backgrounds of the Amplified Plasmodium falciparum Multidrug Resistance (pfmdr1) Gene and Selective Sweep of 184F Mutation in Cambodia

BACKGROUND: The emergence of artesunate-mefloquine (AS+MQ)–resistant Plasmodium falciparum in the Thailand-Cambodia region is a major concern for malaria control. Studies indicate that copy number increase and key alleles in the pfmdr1 gene are associated with AS+MQ resistance. In the present study,...

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Detalhes bibliográficos
Main Authors: Vinayak, Sumiti, Alam, Md Tauqeer, Sem, Rithy, Shah, Naman K., Susanti, Augustina I., Lim, Pharath, Muth, Sinuon, Maguire, Jason D., Rogers, William O., Fandeur, Thierry, Barnwell, John W., Escalante, Ananias A., Wongsrichanalai, Chansuda, Ariey, Frederick, Meshnick, Steven R., Udhayakumar, Venkatachalam
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096139/
https://ncbi.nlm.nih.gov/pubmed/20367478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/651949
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