Active site structure of a beta-hydroxylase in antibiotic biosynthesis

X-ray absorption and resonance Raman spectroscopies show that CmlA, the β-hydroxylase of the chloramphenicol biosynthetic pathway, contains a (μ-oxo)-(μ-1,3-carboxylato)diiron(III) cluster with 6-coordinate iron centers and 3 – 4 His ligands. This active site is found within a unique β-lactamase fol...

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Bibliographic Details
Main Authors: Vu, Van V., Makris, Thomas M., Lipscomb, John D., Que, Lawrence
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096070/
https://ncbi.nlm.nih.gov/pubmed/21506543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201822v
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