Thrombospondin-1–Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis

Thrombospondin-1 (TSP-1) is an extracellular protein critical to normal lung homeostasis, and is reported to activate latent transforming growth factor-β (TGF-β). Because active TGF-β is causally involved in lung fibrosis after bleomycin challenge, alterations in TSP-1 may be relevant to pulmonary f...

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Main Authors: Ezzie, Michael E., Piper, Melissa G., Montague, Christine, Newland, Christie A., Opalek, Judy M., Baran, Chris, Ali, Naeem, Brigstock, David, Lawler, Jack, Marsh, Clay B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095927/
https://ncbi.nlm.nih.gov/pubmed/20581099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0019OC
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