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Endothelial Notch Signaling is Upregulated in Human Brain Arteriovenous Malformations and a Mouse Model of the Disease

Brain arteriovenous malformations (BAVMs) can cause lethal hemorrhagic stroke and have no effective treatment. The cellular and molecular basis for this disease is largely unknown. We have previously shown that expression of constitutively-active Notch4 receptor in the endothelium elicits and mainta...

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Autori principali: Murphy, Patrick A., Lu, Gloria, Shiah, Steven, Bollen, Andrew W., Wang, Rong A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095492/
https://ncbi.nlm.nih.gov/pubmed/19546852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.62
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