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Endothelial Notch Signaling is Upregulated in Human Brain Arteriovenous Malformations and a Mouse Model of the Disease

Brain arteriovenous malformations (BAVMs) can cause lethal hemorrhagic stroke and have no effective treatment. The cellular and molecular basis for this disease is largely unknown. We have previously shown that expression of constitutively-active Notch4 receptor in the endothelium elicits and mainta...

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Detalhes bibliográficos
Main Authors: Murphy, Patrick A., Lu, Gloria, Shiah, Steven, Bollen, Andrew W., Wang, Rong A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095492/
https://ncbi.nlm.nih.gov/pubmed/19546852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.62
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