Identification and Characterization of a Ross River Virus Variant That Grows Persistently in Macrophages, Shows Altered Disease Kinetics in a Mouse Model, and Exhibits Resistance to Type I Interferon

Alphaviruses, such as chikungunya virus, o'nyong-nyong virus, and Ross River virus (RRV), cause outbreaks of human rheumatic disease worldwide. RRV is a positive-sense single-stranded RNA virus endemic to Australia and Papua New Guinea. In this study, we sought to establish an in vitro model of...

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Bibliographic Details
Main Authors: Lidbury, Brett A., Rulli, Nestor E., Musso, Cristina M., Cossetto, Susan B., Zaid, Ali, Suhrbier, Andreas, Rothenfluh, Harald S., Rolph, Michael S., Mahalingam, Suresh
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094974/
https://ncbi.nlm.nih.gov/pubmed/21430046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01189-10
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