Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan

Progress in unraveling the genetic origins of healthy aging is tempered, in part, by a lack of replication of effects, which is often considered a signature of false positive findings. We convincingly demonstrate that the lack of genetic effects on an aging-related trait can be due to trade-offs in...

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Detaylı Bibliyografya
Asıl Yazarlar: Kulminski, Alexander M., Culminskaya, Irina, Ukraintseva, Svetlana V., Arbeev, Konstantin G., Arbeeva, Liubov, Wu, Deqing, Akushevich, Igor, Land, Kenneth C., Yashin, Anatoli I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094490/
https://ncbi.nlm.nih.gov/pubmed/21332925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00689.x
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