Designed Coiled Coils Promote Folding of a Recombinant Bacterial Collagen

Collagen triple helices fold slowly and inefficiently, often requiring adjacent globular domains to assist this process. In the Streptococcus pyogenes collagen-like protein Scl2, a V domain predicted to be largely α-helical, occurs N-terminal to the collagen triple helix (CL). Here, we replace this...

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Autori principali: Yoshizumi, Ayumi, Fletcher, Jordan M., Yu, Zhuoxin, Persikov, Anton V., Bartlett, Gail J., Boyle, Aimee L., Vincent, Thomas L., Woolfson, Derek N., Brodsky, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093825/
https://ncbi.nlm.nih.gov/pubmed/21454493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217364
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