Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

Treacher Collins syndrome (TCS) is a congenital disorder of craniofacial development arising from mutations in TCOF1, which encodes the nucleolar phosphoprotein Treacle. Haploinsufficiency of Tcof1 perturbs mature ribosome biogenesis, resulting in stabilization of p53 and the cyclin G1–mediated cell...

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Bibliografski detalji
Glavni autori: Jones, Natalie C, Lynn, Megan L, Gaudenz, Karin, Sakai, Daisuke, Aoto, Kazushi, Rey, Jean-Phillipe, Glynn, Earl F, Ellington, Lacey, Du, Chunying, Dixon, Jill, Dixon, Michael J, Trainor, Paul A
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093709/
https://ncbi.nlm.nih.gov/pubmed/18246078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1725
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