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Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules

Protein translocation in Escherichia coli is mediated by the translocase that in its minimal form consists of the protein-conducting channel SecYEG, and the motor protein, SecA. SecYEG forms a narrow pore in the membrane that allows passage of unfolded proteins only. Molecular dynamics simulations s...

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Autori principali: Bonardi, Francesco, Halza, Erik, Walko, Martin, Du Plessis, François, Nouwen, Nico, Feringa, Ben L., Driessen, Arnold J. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093497/
https://ncbi.nlm.nih.gov/pubmed/21518907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101705108
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