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Normal Neutrophil Maturation is Associated with Selective Loss of MAP Kinase Activation by G-CSF

Although both GM-CSF and G-CSF activate p42/44 MAPK in neutrophil progenitors, the ability of G-CSF to cause MAPK activation is lost in mature neutrophils, while GM-CSF exposure still causes activation. The mechanism of this differential effect related to maturation status has not been explored. We...

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Bibliographic Details
Main Authors: Baumann, Michael, Frye, Tricia, Naqvi, Tahir, Gomez-Cambronero, Julian
Format: Artigo
Language:Inglês
Published: 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093195/
https://ncbi.nlm.nih.gov/pubmed/15541478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2004.05.009
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