Large scale, liquid phase synthesis of oligonucleotides by the phosphoramidite approach.
A new method for the liquid phase synthesis of oligonucleotides is described which makes use of polyethylene glycol (PEG) as soluble support and phosphoramidite derivatives as synthons. The new synthetic protocol was applied to a quite large scale production (about 100 mumoles) of such compounds up...
Kaydedildi:
| Yayımlandı: | Nucleic Acids Res |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
1993
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| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309284/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8464706/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.5.1213 |
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