Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle

BACKGROUND: The pathogenesis of insulin resistance in the absence of obesity is unknown. In obesity, multiple stress kinases have been identified that impair the insulin signaling pathway via serine phosphorylation of key second messenger proteins. These stress kinases are activated through various...

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Main Authors: Masharani, Umesh B., Maddux, Betty A., Li, Xiaojuan, Sakkas, Giorgos K., Mulligan, Kathleen, Schambelan, Morris, Goldfine, Ira D., Youngren, Jack F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092773/
https://ncbi.nlm.nih.gov/pubmed/21589939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019878
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