Knowledge-Driven Multi-Locus Analysis Reveals Gene-Gene Interactions Influencing HDL Cholesterol Level in Two Independent EMR-Linked Biobanks

Genome-wide association studies (GWAS) are routinely being used to examine the genetic contribution to complex human traits, such as high-density lipoprotein cholesterol (HDL-C). Although HDL-C levels are highly heritable (h(2)∼0.7), the genetic determinants identified through GWAS contribute to a s...

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Detalhes bibliográficos
Main Authors: Turner, Stephen D., Berg, Richard L., Linneman, James G., Peissig, Peggy L., Crawford, Dana C., Denny, Joshua C., Roden, Dan M., McCarty, Catherine A., Ritchie, Marylyn D., Wilke, Russell A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092760/
https://ncbi.nlm.nih.gov/pubmed/21589926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019586
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