FKBP12 is a Critical Regulator of the Heart Rhythm and the Cardiac Voltage-Gated Sodium Current in Mice

BACKGROUND: FK506 binding protein 12 (FKBP12) is a known cis-trans peptidyl prolyl isomerase and highly expressed in the heart. Its role in regulating postnatal cardiac function remains largely unknown. METHODS AND RESULTS: We generated FKBP12 overexpressing transgenic (αMyHC-FKBP12) mice and cardio...

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Auteurs principaux: Maruyama, Mitsunori, Li, Bai-Yan, Chen, Hanying, Xu, Xuehong, Song, Long-Sheng, Zhu, Wuqiang, Yong, Weidong, Zhang, Wenjun, Bu, Gui-Xue, Lin, Shien-Fong, Fishbein, Michael C., Lederer, W. Jonathan, Schild, John H., Field, Loren J., Rubart, Michael, Chen, Peng-Sheng, Shou, Weinian
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092589/
https://ncbi.nlm.nih.gov/pubmed/21372286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.237867
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