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Computational studies of NMDA receptors: differential effects of neuronal activity on efficacy of competitive and non-competitive antagonists

N-Methyl-D-Aspartate receptors (NMDARs) play important physiological as well as pathological roles in the central nervous system (CNS). While NMDAR competitive antagonists, such as D-2-Amino-5-Phosphopentanoic acid (AP5) have been shown to impair learning and memory, the non-competitive antagonist,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ambert, Nicolas, Greget, Renaud, Haeberlé, Olivier, Bischoff, Serge, Berger, Theodore W., Bouteiller, Jean-Marie, Baudry, Michel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092546/
https://ncbi.nlm.nih.gov/pubmed/21572937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OAB.S7246
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