PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention

We show protein kinase C–zeta (PKC-ζ) to be a novel predictive biomarker for survival from prostate cancer (P < 0.001). We also confirm that transcription of the PRKC-ζ gene is crucial to the malignant phenotype of human prostate cancer. Following siRNA silencing of PRKC-ζ in PC3-M prostate cance...

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Autors principals: Yao, Sheng, Bee, Alix, Brewer, Daniel, Dodson, Andrew, Beesley, Carol, Ke, Youqiang, Ambroisine, Laurence, Fisher, Gabrielle, Møller, Heinrich, Dickinson, Tim, Gerard, Patricia, Lian, Lu-Yu, Risk, Janet, Lane, Brian, Smith, Paul, Reuter, Victor, Berney, Daniel, Gosden, Christine, Scardino, Peter, Cuzick, Jack, Djamgoz, Mustafa B.A., Cooper, Colin, Foster, Christopher S.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2010
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092210/
https://ncbi.nlm.nih.gov/pubmed/21779455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910376079
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