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Variance component model to account for sample structure in genome-wide association studies

Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious associations. Variance component approaches, such...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kang, Hyun Min, Sul, Jae Hoon, Service, Susan K, Zaitlen, Noah A, Kong, Sit-yee, Freimer, Nelson B, Sabatti, Chiara, Eskin, Eleazar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092069/
https://ncbi.nlm.nih.gov/pubmed/20208533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.548
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