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Binding and pK(a) Modulation of a Polycyclic Substrate Analog in a Type II Polyketide Acyl Carrier Protein
Type II polyketide synthases are biosynthetic enzymatic pathways responsible for the production of complex aromatic natural products with important biological activities. In these systems, biosynthetic intermediates are covalently bound to a small acyl carrier protein that associates with the syntha...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092034/ https://ncbi.nlm.nih.gov/pubmed/21268653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200004k |
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