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Binding and pK(a) Modulation of a Polycyclic Substrate Analog in a Type II Polyketide Acyl Carrier Protein

Type II polyketide synthases are biosynthetic enzymatic pathways responsible for the production of complex aromatic natural products with important biological activities. In these systems, biosynthetic intermediates are covalently bound to a small acyl carrier protein that associates with the syntha...

詳細記述

保存先:
書誌詳細
主要な著者: Haushalter, Robert W., Filipp, Fabian V., Ko, Kwang-seuk, Yu, Ricky, Opella, Stanley J., Burkart, Michael D.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092034/
https://ncbi.nlm.nih.gov/pubmed/21268653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200004k
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