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Insulin-like Growth Factor-2 (IGF-2) Activates Estrogen Receptor-α and -β via the IGF-1 and the Insulin Receptors in Breast Cancer Cells
The estrogen receptor (ER) is a primary target for breast cancer (BC) treatment. As BC progresses to estrogen-independent growth, the IGF-1R and the ER interact in synergistic crosstalk mechanisms which results in enhanced activation of both receptors signaling cascades. Insulin-like growth factor 2...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092021/ https://ncbi.nlm.nih.gov/pubmed/21410323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08977194.2011.565003 |
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