Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition

External Na(+) self-inhibition is an intrinsic feature of epithelial sodium channels (ENaC). Cpt-cAMP regulates heterologous guinea pig but not rat αβγ ENaC in a ligand-gated manner. We hypothesized that cpt-cAMP may eliminate the self-inhibition of human ENaC thereby open channels. Regulation of se...

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Main Authors: Molina, Raul, Han, Dong-Yun, Su, Xue-Feng, Zhao, Run-Zhen, Zhao, Meimi, Sharp, Gretta M., Chang, Yongchang, Ji, Hong-Long
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091966/
https://ncbi.nlm.nih.gov/pubmed/21419751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2011.03.004
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