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Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition
External Na(+) self-inhibition is an intrinsic feature of epithelial sodium channels (ENaC). Cpt-cAMP regulates heterologous guinea pig but not rat αβγ ENaC in a ligand-gated manner. We hypothesized that cpt-cAMP may eliminate the self-inhibition of human ENaC thereby open channels. Regulation of se...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091966/ https://ncbi.nlm.nih.gov/pubmed/21419751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2011.03.004 |
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