Effect of Single-dose Rifampin on the Pharmacokinetics of Warfarin in Healthy Volunteers

Based on in vitro rat and human hepatocyte uptake studies showing inhibition of warfarin uptake in the presence of the non-specific organic anion transporting polypeptide (OATP) inhibitor rifampin, a clinical study was conducted in 10 healthy volunteers. In a randomized, single-dose, two-period, cro...

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Hlavní autoři: Frymoyer, A, Shugarts, S, Browne, M, Wu, AHB, Frassetto, L, Benet, LZ
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091944/
https://ncbi.nlm.nih.gov/pubmed/20703222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.142
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