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Effect of Single-dose Rifampin on the Pharmacokinetics of Warfarin in Healthy Volunteers
Based on in vitro rat and human hepatocyte uptake studies showing inhibition of warfarin uptake in the presence of the non-specific organic anion transporting polypeptide (OATP) inhibitor rifampin, a clinical study was conducted in 10 healthy volunteers. In a randomized, single-dose, two-period, cro...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091944/ https://ncbi.nlm.nih.gov/pubmed/20703222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.142 |
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