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A Novel Structural Framework for α(1A/D)-Adrenoceptor Selective Antagonists Identified Using Subtype Selective Pharmacophores
In this study four and five-feature pharmacophores for selective antagonists at each of the three α(1)-adrenoceptor (AR) subtypes were used to identify novel α(1)-AR subtype selective compounds in the National Cancer Institute and Tripos LeadQuest databases. 12 compounds were selected, based on dive...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091868/ https://ncbi.nlm.nih.gov/pubmed/21572949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019695 |
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