Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)

The transforming growth factor-β (TGF-β) superfamily of ligands signals along two intracellular pathways, Smad2/3-mediated TGF-β/activin pathway and Smad1/5/8-mediated bone morphogenetic protein pathway. The C terminus of Hsc70-interacting protein (CHIP) serves as an E3 ubiquitin ligase to mediate t...

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Detalhes bibliográficos
Main Authors: Wang, Le, Liu, Yi-Tong, Hao, Rui, Chen, Lei, Chang, Zhijie, Wang, Hong-Rui, Wang, Zhi-Xin, Wu, Jia-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091198/
https://ncbi.nlm.nih.gov/pubmed/21454478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.201814
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