Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts

The CHEK2-1100delC mutation is recurrent in the population and is a moderate risk factor for breast cancer. To identify additional CHEK2 mutations potentially contributing to breast cancer susceptibility, we sequenced 248 cases with early-onset disease; functionally characterized new variants and co...

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Bibliografiset tiedot
Päätekijät: Bell, Daphne W., Kim, Sang H., Godwin, Andrew K., Schiripo, Taryn A., Harris, Patricia L., Haserlat, Sara M., Wahrer, Doke C.R., Haiman, Christopher A., Daly, Mary B., Niendorf, Kristin B., Smith, Matthew R., Sgroi, Dennis C., Garber, Judy E., Olopade, Olufunmilayo I., Marchand, Loic Le, Henderson, Brian E., Altshuler, David, Haber, Daniel A., Freedman, Matthew L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090684/
https://ncbi.nlm.nih.gov/pubmed/17721994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23026
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