Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein -1a

We show mice with a targeted deficiency in the gene encoding the lipogenic transcription factor SREBP-1a are resistant to endotoxic shock and systemic inflammatory response syndrome induced by cecal ligation and puncture (CLP). When macrophages from the mutant mice were challenged with bacterial lip...

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Detalhes bibliográficos
Main Authors: Im, Seung-Soon, Yousef, Leyla, Blaschitz, Christoph, Liu, Janet Z., Edwards, Robert A., Young, Stephen G., Raffatellu, Manuela, Osborne, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090630/
https://ncbi.nlm.nih.gov/pubmed/21531336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.04.001
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