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New Insights into the Binding Mode of Melanin Concentrating Hormone receptor-1 Antagonists: Homology Modeling and Explicit Membrane Molecular Dynamics Simulation Study
Melanin concentrating hormone (MCH) is a cyclic 19-amino-acid peptide expressed mainly in the hypothalamus. It is involved in the control of feeding behavior, energy homeostasis, and body weight. Administration of MCH-R1 antagonists has been proved to reduce food intake and cause weight loss in anim...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3090266/ https://ncbi.nlm.nih.gov/pubmed/21370821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci100355c |
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