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Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice

Elongase of very long chain fatty acids-4 (ELOVL4) is the only mammalian enzyme known to synthesize C28-C36 fatty acids. In humans, ELOVL4 mutations cause Stargardt disease-3 (STGD3), a juvenile dominant macular degeneration. Heterozygous Stgd3 mice that carry a pathogenic mutation in the mouse Elov...

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書誌詳細
主要な著者: McMahon, Anne, Butovich, Igor A., Kedzierski, Wojciech
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090234/
https://ncbi.nlm.nih.gov/pubmed/21429867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014415
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