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The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9
Mutations in the ATRX protein are associated with the alpha-thalassemia and mental retardation X-linked syndrome (ATR-X). Almost half of the disease-causing mutations occur in its ATRX-Dnmt3-Dnmt3L (ADD) domain. By employing peptide arrays, chromatin pull-down and peptide binding assays, we show spe...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3090196/ https://ncbi.nlm.nih.gov/pubmed/21421568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr107 |
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