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Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs
[Image: see text] JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation-transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furtherm...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3089766/ https://ncbi.nlm.nih.gov/pubmed/21452836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200567p |
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