β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A gene is located within the Down Syndrome Critical Region (DSCR) on chromosome 21. We and others have implicated DYRK1A in the phosphorylatio...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Frost, Danielle, Meechoovet, Bessie, Wang, Tong, Gately, Stephen, Giorgetti, Marco, Shcherbakova, Irina, Dunckley, Travis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2011
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089604/
https://ncbi.nlm.nih.gov/pubmed/21573099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019264
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items