Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

While small interfering RNAs (siRNAs) have been rapidly appreciated to silence genes, efficient and non-toxic vectors for primary cells and for systemic in vivo delivery are lacking. Several siRNA-delivery vehicles, including cell-penetrating peptides (CPPs), have been developed but their utility is...

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Detalhes bibliográficos
Main Authors: EL Andaloussi, Samir, Lehto, Taavi, Mäger, Imre, Rosenthal-Aizman, Katri, Oprea, Iulian I., Simonson, Oscar E., Sork, Helena, Ezzat, Kariem, Copolovici, Dana M., Kurrikoff, Kaido, Viola, Joana R., Zaghloul, Eman M., Sillard, Rannar, Johansson, Henrik J., Said Hassane, Fatouma, Guterstam, Peter, Suhorutšenko, Julia, Moreno, Pedro M. D., Oskolkov, Nikita, Hälldin, Jonas, Tedebark, Ulf, Metspalu, Andres, Lebleu, Bernard, Lehtiö, Janne, Smith, C. I. Edvard, Langel, Ülo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Synthetic Biology and Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089457/
https://ncbi.nlm.nih.gov/pubmed/21245043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1299
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