Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

While small interfering RNAs (siRNAs) have been rapidly appreciated to silence genes, efficient and non-toxic vectors for primary cells and for systemic in vivo delivery are lacking. Several siRNA-delivery vehicles, including cell-penetrating peptides (CPPs), have been developed but their utility is...

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Bibliografische gegevens
Hoofdauteurs: EL Andaloussi, Samir, Lehto, Taavi, Mäger, Imre, Rosenthal-Aizman, Katri, Oprea, Iulian I., Simonson, Oscar E., Sork, Helena, Ezzat, Kariem, Copolovici, Dana M., Kurrikoff, Kaido, Viola, Joana R., Zaghloul, Eman M., Sillard, Rannar, Johansson, Henrik J., Said Hassane, Fatouma, Guterstam, Peter, Suhorutšenko, Julia, Moreno, Pedro M. D., Oskolkov, Nikita, Hälldin, Jonas, Tedebark, Ulf, Metspalu, Andres, Lebleu, Bernard, Lehtiö, Janne, Smith, C. I. Edvard, Langel, Ülo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2011
Onderwerpen:
Synthetic Biology and Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089457/
https://ncbi.nlm.nih.gov/pubmed/21245043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1299
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