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Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases

The ability to alter the cytokine microenvironment has the potential to shape immune responses in many physiological settings, including the immunotherapy of tumours. We set out to develop a general approach in which cytokines could be functionally attenuated until activated. We report the developme...

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Hlavní autoři: Puskas, John, Skrombolas, Denise, Sedlacek, Abigail, Lord, Edith, Sullivan, Mark, Frelinger, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088983/
https://ncbi.nlm.nih.gov/pubmed/21426339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2011.03428.x
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