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An empirical assessment of validation practices for molecular classifiers

Proposed molecular classifiers may be overfit to idiosyncrasies of noisy genomic and proteomic data. Cross-validation methods are often used to obtain estimates of classification accuracy, but both simulations and case studies suggest that, when inappropriate methods are used, bias may ensue. Bias c...

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Detalhes bibliográficos
Main Authors: Castaldi, Peter J., Dahabreh, Issa J., Ioannidis, John P.A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088312/
https://ncbi.nlm.nih.gov/pubmed/21300697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bib/bbq073
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