Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target

Novel classes of antimicrobials are needed to address the challenge of multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). Using the architecture of the MRSA interactome, we identified pyruvate kinase (PK) as a potential novel drug target based upon it being a hi...

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Main Authors: Zoraghi, Roya, See, Raymond H., Axerio-Cilies, Peter, Kumar, Nag S., Gong, Huansheng, Moreau, Anne, Hsing, Michael, Kaur, Sukhbir, Swayze, Richard D., Worrall, Liam, Amandoron, Emily, Lian, Tian, Jackson, Linda, Jiang, Jihong, Thorson, Lisa, Labriere, Christophe, Foster, Leonard, Brunham, Robert C., McMaster, William R., Finlay, B. Brett, Strynadka, Natalie C., Cherkasov, Artem, Young, Robert N., Reiner, Neil E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088274/
https://ncbi.nlm.nih.gov/pubmed/21357306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01250-10
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