Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+))-activated T lymphocytes prevents delayed-type hypersensitivity in non-human primates

Lymphocyte-activation gene-3 (LAG-3, CD223) is a marker for recently activated effector T cells. Activated T lymphocytes are of major importance in many autoimmune diseases and organ transplant rejection. Therefore, specifically depleting LAG-3(+) T cells might lead to targeted immunosuppression tha...

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Autori principali: Poirier, N, Haudebourg, T, Brignone, C, Dilek, N, Hervouet, J, Minault, D, Coulon, F, de Silly, R V, Triebel, F, Blancho, G, Vanhove, B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2011
Soggetti:
Animal Models
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087919/
https://ncbi.nlm.nih.gov/pubmed/21352204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2011.04329.x
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