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LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

BACKGROUND: As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membrane protein 2A (LMP2A) in EBV-transformed tumor cells activates the phosphatidy...

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Autori principali: Shin, Jung-Young, Kim, Jeong-Oh, Lee, Suk Kyeong, Chae, Hiun-Suk, Kang, Jin-Hyoung
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087326/
https://ncbi.nlm.nih.gov/pubmed/20704765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-425
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