Nuclear β-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells

BACKGROUND: In breast cancer cells, the metastatic cell state is strongly correlated to epithelial-to-mesenchymal transition (EMT) and the CD44(+)/CD24(- )stem cell phenotype. However, the MCF-7 cell line, which has a luminal epithelial-like phenotype and lacks a CD44(+)/CD24(- )subpopulation, has r...

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Main Authors: Uchino, Masahiro, Kojima, Hiroko, Wada, Kenta, Imada, Mika, Onoda, Fumitoshi, Satofuka, Hiroyuki, Utsugi, Takahiko, Murakami, Yasufumi
格式: Artigo
語言:Inglês
出版: BioMed Central 2010
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087322/
https://ncbi.nlm.nih.gov/pubmed/20696077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-414
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