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Up-Regulation of p18Ink4c Expression by Oncogenic HPV E6 via p53-miR-34a Pathway
Binding of p53 to miR-34a promoter activates the expression of tumor suppressive miR-34a. Oncogenic HPV infection downregulates miR-34a expression through viral E6 degradation of p53. In this report, we found that miR-34a specifically targets p18Ink4c, a CDK4 and CDK6 inhibitor induced by E2F transa...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086996/ https://ncbi.nlm.nih.gov/pubmed/21128241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25800 |
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