Hypertension as a Biomarker of Efficacy in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib

BACKGROUND: Hypertension (HTN) is an on-target effect of the vascular endothelial growth factor pathway inhibitor, sunitinib. We evaluated the association of sunitinib-induced HTN with antitumor efficacy and HTN-associated adverse events in patients with metastatic renal cell carcinoma. METHODS: Thi...

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Autori principali: Rini, Brian I., Cohen, Darrel P., Lu, Dongrui R., Chen, Isan, Hariharan, Subramanian, Gore, Martin E., Figlin, Robert A., Baum, Michael S., Motzer, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086879/
https://ncbi.nlm.nih.gov/pubmed/21527770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djr128
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