Variants in the ITPA Gene Protect Against Ribavirin-Induced Hemolytic Anemia and Decrease the Need for Ribavirin Dose Reduction

BACKGROUND & AIMS: In a genome-wide association study of patients being treated for chronic hepatitis C, 2 functional variants in ITPA that cause inosine triphosphatase (ITPase) deficiency were shown to protect against ribavirin (RBV)-induced hemolytic anemia during early stages of treatment. We...

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Main Authors: Thompson, Alexander. J., Fellay, Jacques, Patel, Keyur, Tillmann, Hans L., Naggie, Susanna, Ge, Dongliang, Urban, Thomas J., Shianna, Kevin V., Muir, Andrew J., Fried, Michael W., Afdhal, Nezam H., Goldstein, David B., Mchutchison, John G.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086671/
https://ncbi.nlm.nih.gov/pubmed/20547162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.06.016
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